Endocrine Abstracts

Good metabolic control depends on the information of blood glucose concentration, routinely obtained with self-monitoring of blood glucose (SMBG). More frequent SMBG is associated with improved metabolic control. In the last decade, real-time continuous glucose monitoring (CGM) of subcutaneous glucose concentration became routinely available and is now introduced into day-to-day management helping people with diabetes make informed decisions on dosing, eating and engaging in p...

People with type 2 Diabetes (T2D) develop severe chronic complication early in the course of the disease if not treated optimally. Although lifestyle intervention and metformin clearly improve metabolic control with metformin having well established safety profile, both become insufficient in most patients with T2D. To achieve the current goal of HbA1c < 7% additional medication are introduced.By current recommendations, basal insulin or sulfonylurea...

Background: Obese individuals may perceive the taste of caloric dense food as less intense, resulting in decreased activation of the reward system. Preclinical research provides some insights into the role of GLP-1 in the gustatory coding. The impact of GLP-1 receptor agonists on the tongue and taste perception remains largely unaddressed in clinical settings.Aim: to investigate the impact of semaglutide on the tongue transcriptome, taste perception and ...

ObjectiveFat depot in the tongue that represents 25–30% of the total tongue mass is largely unaddressed. It correlates with body mass index. The response to weight reduction induced by different anti-obesity modalities may vary between body fat compartments. Semaglutide, a long acting GLP-1 receptor agonist (GLP-1 RA), has the potential to reduce body mass with at least 2 to 3 times greater weight reduction than other studied GLP-1 RAs. This is the ...

Background: The genetic causes of central precocious puberty (CPP) of clinical value identified to date are the paternally inherited Makorin RING-finger protein 3 (MKRN3) and Delta-like homolog 1 (DLK1) deficiencies. Given that CPP is typically maternally inherited, however, the molecular genetic background in the majority of CPP cases remains unknown. Using candidate gene approach focused on genes regulating GnRH secretion and action so far exceedingly rare patients with CPP ...

BackgroundPrenatal dexamethasone treatment (Pdex) has been used since the 1980s to prevent virilization in female offspring suspected to have congenital adrenal hyperplasia (CAH). However, due to lack of strong evidence for its best practice as well as limited data regarding longterm adverse effects, use of dex is highly controversial. This study reveals the current medical practice regarding Pdex in female fetuses at risk of CAH due to 21hydroxylase def...